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KMID : 1161420150180020166
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Journal of Medicinal Food
2015 Volume.18 No. 2 p.166 ~ p.172
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Angelica keiskei Koidzumi Extracts Improve Some Markers of Liver Function in Habitual Alcohol Drinkers: A Randomized Double-Blind Clinical Trial
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Noh Hye-Mi
Ahn Eun-Mi
Yun Jae-Moon
Cho Be-Long
Paek Yu-Jin
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Abstract
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Alcohol induces oxidative stress and inflammatory response, which can lead to hepatitis and cirrhosis. Previous studies reported that the extracts of Angelica keiskei Koidzumi (AKE) have antioxidant and anti-inflammatory properties, suggesting that AKE could improve abnormalities associated with alcoholic liver disease. In this study, the effectiveness of AKE supplementation was assessed in 82 habitual alcohol drinkers (male: more than 14 units per week, female: more than 7 units per week) with abnormal liver biochemistry in a placebo-controlled, randomized double-blind trial over 12 weeks. Among the subjects, 65% (n=43) were heavy drinkers consuming more than 35 units per week. Among heavy drinkers, gamma-glutamyl transferase levels of 19 subjects per AKE-treated group were significantly decreased (21.16±37.63, P=.016) with significant differences observed compared to the 24 subjects per placebo group (P=.046). However, no significant differences were observed in aspartate aminotransferase and alanine aminotransferase levels between the AKE- and placebo-treated groups. These results suggest that AKE supplementation might improve liver function in heavy drinkers.
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KEYWORD
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alcohol, Angelica keiskei Koidzumi, gamma-glutamyl transferase, human, liver diseases
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